GREM1 anticorps (C-Term)

N° du produit ABIN966222

Cet anticorps anti-GREM1 est un anticorps Lapin Polyclonal détectant GREM1 dans WB. Adapté pour Humain. Ce Primary Antibody a été cité dans 4+ publications.

Aperçu rapide pour GREM1 anticorps (C-Term) (ABIN966222)

Antigène: GREM1 (Gremlin 1 (GREM1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GREM1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-GREM1 anticorps

Épitope: C-Term

Réactivité croisée: Souris, Rat (Rattus)

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Gremlin-1 (GREM1) detection. Tested with WB in Human, Mouse, Rat.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminal of human Gremlin 1, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide, Thimerosal (Merthiolate)

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.

Références pour anticorps anti-GREM1 (ABIN966222)

Stabile, Mitola, Moroni, Belleri, Nicoli, Coltrini, Peri, Pessi, Orsatti, Talamo, Castronovo, Waltregny, Cotelli, Ribatti, Presta: "Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor." dans: Blood, Vol. 109, Issue 5, pp. 1834-40, (2007) (PubMed).

Namkoong, Shin, Kim, Ha, Cho, Hur, Kim, Kim: "The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein." dans: BMC cancer, Vol. 6, pp. 74, (2006) (PubMed).

Sox: "Office-based testing for fecal occult blood: do only in case of emergency." dans: Annals of internal medicine, Vol. 142, Issue 2, pp. 146-8, (2005) (PubMed).

Gazzerro, Pereira, Jorgetti, Olson, Economides, Canalis: "Skeletal overexpression of gremlin impairs bone formation and causes osteopenia." dans: Endocrinology, Vol. 146, Issue 2, pp. 655-65, (2005) (PubMed).

Détails sur GREM1

Antigène: GREM1 (Gremlin 1 (GREM1))

Autre désignation: Gremlin-1

Sujet: Gremlin, also known as Drm, is a highly conserved 20. 7-kDa, 184 amino acid glycoprotein part of the DAN family and is a cysteine knot-secreted protein. Skeletal cells synthesize bone morphogenetic proteins (BMPs) and BMP antagonists. And Gremlin is expressed in osteoblasts and opposes BMP effects on osteoblastic differentiation and function in vitro. Gremlin 1 (GREM 1) is known for its antagonistic reaction with BMPs in the TGF beta signaling pathway. This gene inhibits BMP-2, BMP-4, and BMP-7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development. Gremlin 1 may play an oncogenic role especially in carcinomas of the uterine cervix, lung, ovary, kidney, breast, colon, pancreas, and sarcoma. Over-expressed gremlin 1 functions by interaction with YWHAH (Its binding site for gremlin 1 was located between residues 61-80 and gremlin 1 binding site for YWHAH was found to be located between residues 1-67). Therefore, Gremlin 1 and its binding protein YWHAH could be good targets for developing diagnostic and therapeutic strategies against human cancers.

Pathways: Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location